Tumor Suppressor Genes

TUMOR SUPPRESSOR GENES
GENE -- ASSOCIATED TUMOR -- GENE PRODUCT
1) BRCA1 & 2 -- breast & ovarian ca -- DNA repair protein
2) NF1 -- Neurofibromatosis 1 -- RAS GTPase activating protein - neurofibromin
3) NF2 -- Neurofibromatosis 2 -- Merlin protein
4) APC -- FAP
5) WT1 & WT2 -- Wilms tumor
6) PTEN -- Cowden syndrome breast, prostate & endometrial ca
7) p16 -- Melanoma -- cyclin dependent kinase inhibitor 2A (CDKi2A)
8) p53 -- Most human cancers, Li-Fraumeni syndrome -- Transcription factor for p21, blocks G1 - S phase
9) Rb -- Retinblastoma, Osteosarcoma -- Inhibits E2F, blocks G1-S phase
10) MEN1 -- MEN type 1
11) TSC1 -- Tuberous sclerosis -- Hamartin
12) TSC2 -- Tuberous sclerosis -- Tuberin