Delamanid (OPC-67683; nitrodihydro imidazooxazole derivative) it inhibits mycolic acid synthesis with a great efficacy against multidrug-resistant strains of M. tuberculosis. No significant adverse events and no cross-resistance have been reported.
Bedaquiline ( Sirturo; Janssen Therapeutics) diarylquinoline for MDR &XDR TB, FDA Approved December 2012, it inhibits ATP synthesis (energy production) by inhibiting ATP synthase. It may produce arrhythmias and cardiac arrest.
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