Influenza

INFLUENZA VIRUS
Asked Points :

Influenza A - Hemagglutinin and neuraminidase is strain specific

Influenza - Primary infectious pneumonia is less common than secondary bacterial pneumonia

Influenza - Major epidemics are due to antigenic SHIFT, Antigenic drift is gradual antigenic

change over a period of time, Antigenic shift is due to genetic recombination of virus, Influenza

A is subjected to frequent antigenic variations Segmented RNA - Influenza

H5N1 - Bird flu virus

Gradual and sequential change in antigenic structure at regular intervals - Antigenic drift

Influenza causes new epidemic by - Antigenicndrift

Antigenic shift - Gradual

Antigenic variation NOT seen in - Influenza C

Influenza - Affects all sexes and ages, Incubation period 18 – 72 hours

Immunofluorescence - Detection of influenza

Amantidine is most effective for - Influenza A

Which is a Neuraminidase Inhibitor - Oseltamivir

Avian influenza treated by - Oseltamivir

Oseltamivir is used to treat - Influenza A & B

Newer influenza vaccine - Split virus vaccine,

Neuraminidase, Recombinant vaccine

Harrison Points :

H1N1 swine flu was found on - 2009

Influenza is associated with - Myositis and rhabdomyolysis

Most serious complication of Influenza B - Reye syndrome

Amantidine and rimantidine are active against - Influenza A only

Oseltamivir inhibit - Neuraminidase

Additional Points :

Segmented RNA virus - Influenza virus

M protein in orthomyxovirus maturation - Serves as a recognition site for nucleocapsid at the

inner face of plasma membrane

All pandemic of influenza by - Influenza A only

Pandemic of influenza is caused by - Antigenic shift

Shift occurs only with - Influenza A

Reye syndrome is associated with - Influenza B

Mechanism of action of oseltamivir - Inhibition of a viral enzyme that aids the spread of virus

through respiratory mucus and is required for release of progeny virus

Dose of oseltamivir in adults - 75 mg BD