ML & DOWN SYNDROME

ML & DOWN SYNDROME
1. Down Syndrome kids have 150 fold RISK of AML by 5 years
2. MC AML subtype in Down syndrome is AML M7.
3. AML M7 is the MC leukemia in Kids < 3 years with Down syndrome
4. Children with Down syndrome and AML comprise 10% of all pediatric AML cases.
5 . ALL INFANTS WITH DOWN SYNDROME ARE CONSIDERED HIGH RISK FOR AML.
6. HIGHEST RISK of AML in Down syndrome is between 1-3 years age.. Those kids >4years and getting AML have a SIGNIFICANTLY LESSER SURVIVAL RATE compared to those <4years of age
7. Mutation in GATA-1 gene is present in all Down syndrome kids with Transient Myeloproliferative Disorder (TMD) and AML M7.
8. IN GENERAL Down syndrome kids with AML have better prognosis than NON-Down syndrome KIDS with AML!!