SSRI

✅✅POINTS TO REMEMBER IN SSRI :

✅1. first ssri discovered was fluoxetine
✅2. only ssri approved for childhood depression - fluoxetine
✅3. longest half life - fluoxetine
✅4. does not require dose tapering/does not cause withdrawal - fluoxetine
✅ 5. ssri having maximum anticholinergic effect - paroxetine

✅6. ssri having maximum sedation - paroxetine
✅7. ssri least safe in elderly - paroxetine 
✅8. Fluvoxamine, paroxetine, sertraline, and fluoxetine are indicated for treatment of OCD in persons over the age of 18 years. 
✅9. Fluvoxamine and sertraline have also been approved for treatment of pediatric OCD (ages 6 to 17)
✅10. most common long term associated side effects of ssri - sexual dysfunction(manifests as anorgasmia)... it does not decrease with continued usage
✅11. mc side effects are gi side effects (bcoz of 5ht3 receptors) include nausea, diarrhea, anorexia, vomiting, flatulence, and dyspepsia... (aiims question loose stools >> anxiety)  
✅12. mc ssri implicated in causing paradoxical anxiety - fluoxetine
✅  13. mc ssri blamed to cause increase in suicidal risk especially in children - fluoxetine 
✅14. mc ssri causing insomnia - fluoxetine
✅15. ssri with shortest half life - fluvoxamine
✅16 .ssri with most enzyme inhibition - fluvoxamine 
✅17.ssri with most drug interactions - fluvoxamine 
✅18.all ssri are us fda approved for depression except - fluvoxamine
✅19.  rare s.e of ssri includes - SIADH..