GIST

GASTROINTESTINAL STROMAL TUMOR (GIST)
Most common mesenchymal tumours of
STOMACH.

Most common site is stomach
interstitial cells of Cajal ( pacemaker cells of
GIT)

IHC markers -
CD 117 c kit)(80%);
PDGFR- alpha gene(15%);
CD 34, DOG 1 (MOST SPECIFIC and BEST FOR DIAGNOSIS)
associated with Carneys triad- gastric GIST,
pulmonary chondroma, extra adrenal
paraganglioma

Prognosis in GIST is dependent on- number of mitosis >>> size of tumor