Endocrine Hormones and Disorders
Hyposecretion of Anti-Diuretic Hormone - Diabetes insipidus
Due to decreased production of anti-diuretic hormone in the supraoptic nucleus of the hypothalamus. Often associated with a head injury.
Symptoms: Excessive diuresis and thirst (polyuria and polydipsia).
Hyposecretion of Growth hormone - Pituitary dwarfism
Due to decreased production of growth hormone from the somatotropic cells of the anterior pituitary. Generally due to a nonmalignant adenoma of the non-somatotropic tissue of the anterior pituitary.
Symptoms:
1. Pronounced hypoglycemia.
2. In Lorain dwarfism:
a. arrested sexual development
b. stunted growth
c. normal intelligence
3. In Frolich's dwarfism:
a. arrested sexual development
b. stunted growth
c. mental retardation
Hypersecretion of growth hormone - Giantism and Acromegaly
Pituitary giantism is due to overproduction of growth hormone during childhood. Usually caused by an adenoma of the somatotropic cells.
Symptoms: Excessive growth, hyperglycemia, diabetes mellitus, osteoporosis and high basal metabolic rate (BMR).
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